Gene information
Official symbol TNFSF12
Official full name TNF superfamily member 12
Gene type protein-coding gene
Chromosome17p13.1
Alias symbolTWEAK; DR3LG; APO3L
Gene familyTumor necrosis factor superfamily
Resources
Entrez Gene 8742
HGNC HGNC:11927
Ensembl ENSG00000239697
Vega OTTHUMG00000108148
UCSC uc002ghg.4
GO terms: 37 records
GO Description Category LogP Number of genes Detail
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001667 ameboidal-type cell migration GO Biological Processes -17.0771232 40 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0001938 positive regulation of endothelial cell proliferation GO Biological Processes -32.0012114 45 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005164 tumor necrosis factor receptor binding GO Molecular Functions -5.56986570 6 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0010631 epithelial cell migration GO Biological Processes -10.0481870 21 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0032813 tumor necrosis factor receptor superfamily binding GO Molecular Functions -5.47819787 7 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0042176 regulation of protein catabolic process GO Biological Processes -8.45353494 23 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043542 endothelial cell migration GO Biological Processes -10.6625063 19 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048471 perinuclear region of cytoplasm GO Cellular Components -8.50169248 66 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050679 positive regulation of epithelial cell proliferation GO Biological Processes -31.4834672 59 More
GO:0090130 tissue migration GO Biological Processes -11.7623300 24 More
GO:0090132 epithelium migration GO Biological Processes -9.75855830 21 More
GO:0097190 apoptotic signaling pathway GO Biological Processes -11.7839485 23 More
GO:0097191 extrinsic apoptotic signaling pathway GO Biological Processes -9.74858067 13 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001235 positive regulation of apoptotic signaling pathway GO Biological Processes -13.4065813 30 More
GO:2001236 regulation of extrinsic apoptotic signaling pathway GO Biological Processes -20.7647111 26 More
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway GO Biological Processes -7.00132107 13 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
ro-5458640 TTD 24135629 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
tumor necrosis factor ligand superfamily member 12 proteomics poor predictor adverse events[prognosis (bad)] acute ST elevation myocardial infarction Chorianopoulos E et al. Atherosclerosis. 2010
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